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Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na(+)/K(+)-ATPase

Glycoprotein nonmetastatic melanoma protein B (GPNMB) plays important roles in various types of cancer and amyotrophic lateral sclerosis (ALS). The details of GPNMB function and its interacting protein have not been clarified. Therefore, to identify GPNMB binding partners on the cell membrane, we us...

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Detalles Bibliográficos
Autores principales: Ono, Yoko, Tsuruma, Kazuhiro, Takata, Masafumi, Shimazawa, Masamitsu, Hara, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796790/
https://www.ncbi.nlm.nih.gov/pubmed/26988030
http://dx.doi.org/10.1038/srep23241