Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade

Bacterial infection-induced sepsis is the leading cause of septic inflammatory disease. Rhodostomin (Rn), a snake venom disintegrin, was previously reported to interact with the αVβ3 integrin and the TLR4 on phagocyte in attenuating LPS-induced endotoxemia. In this report, we further evaluated the e...

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Detalles Bibliográficos
Autores principales: Hsu, Chun-Chieh, Chuang, Woei-Jer, Chung, Ching-Hu, Chang, Chien-Hsin, Peng, Hui-Chin, Huang, Tur-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796821/
https://www.ncbi.nlm.nih.gov/pubmed/26987407
http://dx.doi.org/10.1038/srep23387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796821/
https://www.ncbi.nlm.nih.gov/pubmed/26987407
http://dx.doi.org/10.1038/srep23387

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