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Biological insertion of computationally designed short transmembrane segments

The great majority of helical membrane proteins are inserted co-translationally into the ER membrane through a continuous ribosome-translocon channel. The efficiency of membrane insertion depends on transmembrane (TM) helix amino acid composition, the helix length and the position of the amino acids...

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Detalles Bibliográficos
Autores principales: Baeza-Delgado, Carlos, von Heijne, Gunnar, Marti-Renom, Marc A., Mingarro, Ismael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796907/
https://www.ncbi.nlm.nih.gov/pubmed/26987712
http://dx.doi.org/10.1038/srep23397