Mutation of exposed hydrophobic amino acids to arginine to increase protein stability

BACKGROUND: One strategy to increase the stability of proteins is to reduce the area of water-accessible hydrophobic surface. RESULTS: In order to test it, we replaced 14 solvent-exposed hydrophobic residues of acetylcholinesterase by arginine. The stabilities of the resulting proteins were tested u...

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Detalles Bibliográficos
Autores principales: Strub, Caroline, Alies, Carole, Lougarre, Andrée, Ladurantie, Caroline, Czaplicki, Jerzy, Fournier, Didier
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC479692/
https://www.ncbi.nlm.nih.gov/pubmed/15251041
http://dx.doi.org/10.1186/1471-2091-5-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC479692/
https://www.ncbi.nlm.nih.gov/pubmed/15251041
http://dx.doi.org/10.1186/1471-2091-5-9

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