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Mutation of exposed hydrophobic amino acids to arginine to increase protein stability
BACKGROUND: One strategy to increase the stability of proteins is to reduce the area of water-accessible hydrophobic surface. RESULTS: In order to test it, we replaced 14 solvent-exposed hydrophobic residues of acetylcholinesterase by arginine. The stabilities of the resulting proteins were tested u...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC479692/ https://www.ncbi.nlm.nih.gov/pubmed/15251041 http://dx.doi.org/10.1186/1471-2091-5-9 |