Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA

Oxidation of a DNA thymine to 5-hydroxymethyluracil is one of several recently discovered epigenetic modifications. Here, we report the results of nanopore translocation experiments and molecular dynamics simulations that provide insight into the impact of this modification on the structure and dyna...

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Detalles Bibliográficos
Autores principales: Carson, Spencer, Wilson, James, Aksimentiev, Aleksei, Weigele, Peter R., Wanunu, Meni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797264/
https://www.ncbi.nlm.nih.gov/pubmed/26578595
http://dx.doi.org/10.1093/nar/gkv1199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797264/
https://www.ncbi.nlm.nih.gov/pubmed/26578595
http://dx.doi.org/10.1093/nar/gkv1199

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