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Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA
Oxidation of a DNA thymine to 5-hydroxymethyluracil is one of several recently discovered epigenetic modifications. Here, we report the results of nanopore translocation experiments and molecular dynamics simulations that provide insight into the impact of this modification on the structure and dyna...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797264/ https://www.ncbi.nlm.nih.gov/pubmed/26578595 http://dx.doi.org/10.1093/nar/gkv1199 |