Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction

The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive...

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Detalles Bibliográficos
Autores principales: Thayer, Kelly M., Beyer, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798270/
https://www.ncbi.nlm.nih.gov/pubmed/26992014
http://dx.doi.org/10.1371/journal.pone.0147806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798270/
https://www.ncbi.nlm.nih.gov/pubmed/26992014
http://dx.doi.org/10.1371/journal.pone.0147806

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