PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice

BACKGROUND: Islet transplantation may potentially cure type 1 diabetes mellitus (T1DM). However, immune rejection, especially that induced by the alloreactive T-cell response, remains a restraining factor for the long-term survival of grafted islets. Programmed death ligand-1 (PD-L1) is a negative c...

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Detalles Bibliográficos
Autores principales: Ma, Dongxia, Duan, Wu, Li, Yakun, Wang, Zhimin, Li, Shanglin, Gong, Nianqiao, Chen, Gang, Chen, Zhishui, Wan, Chidan, Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798758/
https://www.ncbi.nlm.nih.gov/pubmed/26990974
http://dx.doi.org/10.1371/journal.pone.0152087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798758/
https://www.ncbi.nlm.nih.gov/pubmed/26990974
http://dx.doi.org/10.1371/journal.pone.0152087

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