Conversion of leucine to β‐hydroxy‐β‐methylbutyrate by α‐keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes

BACKGROUND: L‐Leu and its metabolite β‐hydroxy‐β‐methylbutyrate (HMB) stimulate muscle protein synthesis enhancing the phosphorylation of proteins that regulate anabolic signalling pathways. Alterations in these pathways are observed in many catabolic diseases, and HMB and L‐Leu have proven their an...

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Detalles Bibliográficos
Autores principales: Girón, María D., Vílchez, José D., Salto, Rafael, Manzano, Manuel, Sevillano, Natalia, Campos, Nefertiti, Argilés, Josep M., Rueda, Ricardo, López‐Pedrosa, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799859/
https://www.ncbi.nlm.nih.gov/pubmed/27065075
http://dx.doi.org/10.1002/jcsm.12032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799859/
https://www.ncbi.nlm.nih.gov/pubmed/27065075
http://dx.doi.org/10.1002/jcsm.12032

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