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Population pharmacokinetics of tanezumab in phase 3 clinical trials for osteoarthritis pain

AIMS: The aims were to 1) develop the pharmacokinetics model to describe and predict observed tanezumab concentrations over time, 2) test possible covariate parameter relationships that could influence clearance and distribution and 3) assess the impact of fixed dosing vs. a dosing regimen adjusted...

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Detalles Bibliográficos
Autores principales: Jonsson, E. Niclas, Xie, Rujia, Marshall, Scott F., Arends, Rosalin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799925/
https://www.ncbi.nlm.nih.gov/pubmed/26613544
http://dx.doi.org/10.1111/bcp.12850