Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities

Immunological adjuvants such as the saponin natural product QS-21 help stimulate the immune response to co-administered antigens and have become increasingly important in the development of prophylactic and therapeutic vaccines. However, clinical use of QS-21 is encumbered by chemical instability, d...

Descripción completa

Detalles Bibliográficos
Autores principales: Walkowicz, William E., Fernández-Tejada, Alberto, George, Constantine, Corzana, Francisco, Jiménez-Barbero, Jesús, Ragupathi, Govind, Tan, Derek S., Gin, David Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800320/
https://www.ncbi.nlm.nih.gov/pubmed/27014435
http://dx.doi.org/10.1039/c5sc02978c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800320/
https://www.ncbi.nlm.nih.gov/pubmed/27014435
http://dx.doi.org/10.1039/c5sc02978c

Ejemplares similares