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Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities

Immunological adjuvants such as the saponin natural product QS-21 help stimulate the immune response to co-administered antigens and have become increasingly important in the development of prophylactic and therapeutic vaccines. However, clinical use of QS-21 is encumbered by chemical instability, d...

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Detalles Bibliográficos
Autores principales:	Walkowicz, William E., Fernández-Tejada, Alberto, George, Constantine, Corzana, Francisco, Jiménez-Barbero, Jesús, Ragupathi, Govind, Tan, Derek S., Gin, David Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800320/ https://www.ncbi.nlm.nih.gov/pubmed/27014435 http://dx.doi.org/10.1039/c5sc02978c

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