The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes

To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells. Contrary to the accepted model of microbial membrane disruption...

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Detalles Bibliográficos
Autores principales: Chindera, Kantaraja, Mahato, Manohar, Kumar Sharma, Ashwani, Horsley, Harry, Kloc-Muniak, Klaudia, Kamaruzzaman, Nor Fadhilah, Kumar, Satish, McFarlane, Alexander, Stach, Jem, Bentin, Thomas, Good, Liam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800398/
https://www.ncbi.nlm.nih.gov/pubmed/26996206
http://dx.doi.org/10.1038/srep23121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800398/
https://www.ncbi.nlm.nih.gov/pubmed/26996206
http://dx.doi.org/10.1038/srep23121

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