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VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation

Imbalanced protein homeostasis, such as excessive protein synthesis and protein aggregation, is a pathogenic hallmark of a range of neurological disorders. Here, using expression of mutant proteins, a knockdown approach and disease mutation knockin mice, we show that VCP (valosin-containing protein)...

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Detalles Bibliográficos
Autores principales: Shih, Yu-Tzu, Hsueh, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800434/
https://www.ncbi.nlm.nih.gov/pubmed/26984393
http://dx.doi.org/10.1038/ncomms11020