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VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
Imbalanced protein homeostasis, such as excessive protein synthesis and protein aggregation, is a pathogenic hallmark of a range of neurological disorders. Here, using expression of mutant proteins, a knockdown approach and disease mutation knockin mice, we show that VCP (valosin-containing protein)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800434/ https://www.ncbi.nlm.nih.gov/pubmed/26984393 http://dx.doi.org/10.1038/ncomms11020 |