Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation

Accumulation of methylglyoxal (MG) contributes to glucotoxicity and mediates beta cell apoptosis. The molecular mechanism by which GLP-1 protects MG-induced beta cell apoptosis remains unclear. Metformin is a first-line drug for treating type 2 diabetes associated with AMPK activation. However, whet...

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Detalles Bibliográficos
Autores principales: Chang, Tien-Jyun, Tseng, Hsing-Chi, Liu, Meng-Wei, Chang, Yi-Cheng, Hsieh, Meng-Lun, Chuang, Lee-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800673/
https://www.ncbi.nlm.nih.gov/pubmed/26997114
http://dx.doi.org/10.1038/srep23403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800673/
https://www.ncbi.nlm.nih.gov/pubmed/26997114
http://dx.doi.org/10.1038/srep23403

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