MTH1 Substrate Recognition—An Example of Specific Promiscuity

MTH1 (NUDT1) is an oncologic target involved in the prevention of DNA damage. We investigate the way MTH1 recognises its substrates and present substrate-bound structures of MTH1 for 8-oxo-dGTP and 8-oxo-rATP as examples of novel strong and weak binding substrate motifs. Investigation of a small set...

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Detalles Bibliográficos
Autores principales: Nissink, J. Willem M., Bista, Michal, Breed, Jason, Carter, Nikki, Embrey, Kevin, Read, Jonathan, Winter-Holt, Jon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801406/
https://www.ncbi.nlm.nih.gov/pubmed/26999531
http://dx.doi.org/10.1371/journal.pone.0151154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801406/
https://www.ncbi.nlm.nih.gov/pubmed/26999531
http://dx.doi.org/10.1371/journal.pone.0151154

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