Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription

BACKGROUND: Neurobeachin (NBEA) is an autism spectrum disorders (ASD) candidate gene. NBEA deficiency affects regulated secretion, receptor trafficking, synaptic architecture and protein kinase A (PKA)-mediated phosphorylation. NBEA is a large multidomain scaffolding protein. From N- to C-terminus,...

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Detalles Bibliográficos
Autores principales: Tuand, Krizia, Stijnen, Pieter, Volders, Karolien, Declercq, Jeroen, Nuytens, Kim, Meulemans, Sandra, Creemers, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801420/
https://www.ncbi.nlm.nih.gov/pubmed/26999814
http://dx.doi.org/10.1371/journal.pone.0151954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801420/
https://www.ncbi.nlm.nih.gov/pubmed/26999814
http://dx.doi.org/10.1371/journal.pone.0151954

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