Cargando…
The colorectal cancer immune paradox revisited
Tumor infiltrating lymphocytes (TILs) represent a strong independent predictor of relapse and overall survival in colorectal cancer (CRC). However, it appears that a majority of CRCs, i.e., microsatellite stable (MSS) tumors, are refractory to immune checkpoint blockers. The results of recent compre...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801462/ https://www.ncbi.nlm.nih.gov/pubmed/27057454 http://dx.doi.org/10.1080/2162402X.2015.1078058 |
_version_ | 1782422583692492800 |
---|---|
author | Angelova, Mihaela Charoentong, Pornpimol Hackl, Hubert Trajanoski, Z. |
author_facet | Angelova, Mihaela Charoentong, Pornpimol Hackl, Hubert Trajanoski, Z. |
author_sort | Angelova, Mihaela |
collection | PubMed |
description | Tumor infiltrating lymphocytes (TILs) represent a strong independent predictor of relapse and overall survival in colorectal cancer (CRC). However, it appears that a majority of CRCs, i.e., microsatellite stable (MSS) tumors, are refractory to immune checkpoint blockers. The results of recent comprehensive analyses of genomic data provide possible answers. |
format | Online Article Text |
id | pubmed-4801462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48014622016-04-07 The colorectal cancer immune paradox revisited Angelova, Mihaela Charoentong, Pornpimol Hackl, Hubert Trajanoski, Z. Oncoimmunology Author's View Tumor infiltrating lymphocytes (TILs) represent a strong independent predictor of relapse and overall survival in colorectal cancer (CRC). However, it appears that a majority of CRCs, i.e., microsatellite stable (MSS) tumors, are refractory to immune checkpoint blockers. The results of recent comprehensive analyses of genomic data provide possible answers. Taylor & Francis 2015-08-27 /pmc/articles/PMC4801462/ /pubmed/27057454 http://dx.doi.org/10.1080/2162402X.2015.1078058 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Author's View Angelova, Mihaela Charoentong, Pornpimol Hackl, Hubert Trajanoski, Z. The colorectal cancer immune paradox revisited |
title | The colorectal cancer immune paradox revisited |
title_full | The colorectal cancer immune paradox revisited |
title_fullStr | The colorectal cancer immune paradox revisited |
title_full_unstemmed | The colorectal cancer immune paradox revisited |
title_short | The colorectal cancer immune paradox revisited |
title_sort | colorectal cancer immune paradox revisited |
topic | Author's View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801462/ https://www.ncbi.nlm.nih.gov/pubmed/27057454 http://dx.doi.org/10.1080/2162402X.2015.1078058 |
work_keys_str_mv | AT angelovamihaela thecolorectalcancerimmuneparadoxrevisited AT charoentongpornpimol thecolorectalcancerimmuneparadoxrevisited AT hacklhubert thecolorectalcancerimmuneparadoxrevisited AT trajanoskiz thecolorectalcancerimmuneparadoxrevisited AT angelovamihaela colorectalcancerimmuneparadoxrevisited AT charoentongpornpimol colorectalcancerimmuneparadoxrevisited AT hacklhubert colorectalcancerimmuneparadoxrevisited AT trajanoskiz colorectalcancerimmuneparadoxrevisited |