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Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program

Metazoan development is regulated by transcriptional networks, which must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly conserved regulatory module, activated by many cytokines, in which tyrosine‐phosphorylated STATs (pSTATs) function as transcription factors. H...

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Detalles Bibliográficos
Autores principales: Park, Hyun Jung, Li, Juan, Hannah, Rebecca, Biddie, Simon, Leal‐Cervantes, Ana I, Kirschner, Kristina, Flores Santa Cruz, David, Sexl, Veronika, Göttgens, Berthold, Green, Anthony R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801948/
https://www.ncbi.nlm.nih.gov/pubmed/26702099
http://dx.doi.org/10.15252/embj.201592383