Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction that is essential for bone development, however, how IFT proteins regulate Hh signalling in osteoblasts (OBs) remains unclear. Here we show that deletion of ciliary IFT80 in OB precursor cells (OPC) in mic...

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Detalles Bibliográficos
Autores principales: Yuan, Xue, Cao, Jay, He, Xiaoning, Serra, Rosa, Qu, Jun, Cao, Xu, Yang, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802171/
https://www.ncbi.nlm.nih.gov/pubmed/26996322
http://dx.doi.org/10.1038/ncomms11024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802171/
https://www.ncbi.nlm.nih.gov/pubmed/26996322
http://dx.doi.org/10.1038/ncomms11024

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