Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans

DNA methylation likely plays a role in the regulation of human stress reactivity. Here we show that in a genome-wide analysis of blood DNA methylation in 85 healthy individuals, a locus in the Kit ligand gene (KITLG; cg27512205) showed the strongest association with cortisol stress reactivity (P=5.8...

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Detalles Bibliográficos
Autores principales: Houtepen, Lotte C., Vinkers, Christiaan H., Carrillo-Roa, Tania, Hiemstra, Marieke, van Lier, Pol A., Meeus, Wim, Branje, Susan, Heim, Christine M., Nemeroff, Charles B., Mill, Jonathan, Schalkwyk, Leonard C., Creyghton, Menno P., Kahn, René S., Joëls, Marian, Binder, Elisabeth B., Boks, Marco P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802173/
https://www.ncbi.nlm.nih.gov/pubmed/26997371
http://dx.doi.org/10.1038/ncomms10967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802173/
https://www.ncbi.nlm.nih.gov/pubmed/26997371
http://dx.doi.org/10.1038/ncomms10967

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