BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence

The BRE gene, alias BRCC45, produces a 44 kDa protein that is normally distributed in both cytoplasm and nucleus. In this study, we used adult fibroblasts isolated from wild-type (WT) and BRE knockout (BRE(−/−)) mice to investigate the functional role of BRE in DNA repair and cellular senescence. We...

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Detalles Bibliográficos
Autores principales: Shi, Wenting, Tang, Mei Kuen, Yao, Yao, Tang, Chengcheng, Chui, Yiu Loon, Lee, Kenneth Ka Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802329/
https://www.ncbi.nlm.nih.gov/pubmed/27001068
http://dx.doi.org/10.1038/srep23506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802329/
https://www.ncbi.nlm.nih.gov/pubmed/27001068
http://dx.doi.org/10.1038/srep23506

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