Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks

2-Ethylphenyl 4-(3-ethylureido)benzenesulfonate (SFOM-0046) is a novel anticancer agent that arrests cell cycle in S-phase and causes DNA replication stress leading to the phosphorylation of H2AX into γ-H2AX. First, using the M21, HT29, HT-1080 and HeLa cell lines, we confirmed that S-phase cell cyc...

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Detalles Bibliográficos
Autores principales: Pauty, Joris, Côté, Marie-France, Rodrigue, Amélie, Velic, Denis, Masson, Jean-Yves, Fortin, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802344/
https://www.ncbi.nlm.nih.gov/pubmed/27001483
http://dx.doi.org/10.1038/srep23302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802344/
https://www.ncbi.nlm.nih.gov/pubmed/27001483
http://dx.doi.org/10.1038/srep23302

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