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A Dynamical Framework for the All-or-None G1/S Transition

The transition from G1 into DNA replication (S phase) is an emergent behavior resulting from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk inhibitors (CKIs), and the anaphase-promoting complex/cyclosome (APC/C). Understanding the cellular decision to commit to S phase...

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Detalles Bibliográficos
Autores principales: Barr, Alexis R., Heldt, Frank S., Zhang, Tongli, Bakal, Chris, Novák, Béla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802413/
https://www.ncbi.nlm.nih.gov/pubmed/27136687
http://dx.doi.org/10.1016/j.cels.2016.01.001