Cargando…

Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis

BACKGROUND: Rheumatoid arthritis is a systemic inflammatory condition associated with increased cardiovascular risk that may be due to underlying endothelial dysfunction and subsequent aortic stiffening. We hypothesized that supplementation with tetrahydrobiopterin (BH (4)) would recouple endothelia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mäki‐Petäjä, Kaisa M., Day, Lisa, Cheriyan, Joseph, Hall, Frances C., Östör, Andrew J. K., Shenker, Nicholas, Wilkinson, Ian B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802470/ https://www.ncbi.nlm.nih.gov/pubmed/26896473 http://dx.doi.org/10.1161/JAHA.115.002762

Ejemplares similares

The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness
por: Mäki-Petäjä, Kaisa M., et al.
Publicado: (2016)

Effects of Oral Lycopene Supplementation on Vascular Function in Patients with Cardiovascular Disease and Healthy Volunteers: A Randomised Controlled Trial
por: Gajendragadkar, Parag R., et al.
Publicado: (2014)

A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice
por: Chuaiphichai, Surawee, et al.
Publicado: (2017)

Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase
por: Tobias, Silke, et al.
Publicado: (2015)

Are aortic coarctation and rheumatoid arthritis different models of aortic stiffness? Data from an echocardiographic study
por: Faganello, Giorgio, et al.
Publicado: (2018)

Effects of 6 months of abatacept treatment on aortic stiffness in patients with rheumatoid arthritis
por: Mathieu, Sylvain, et al.
Publicado: (2013)

Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia
por: Leiva, Andrea, et al.
Publicado: (2016)

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
por: Bailey, Jade, et al.
Publicado: (2017)

Refining the Management of Rheumatoid Arthritis: the Benefits of Subcutaneous Tocilizumab
por: Negoescu, Andra F., et al.
Publicado: (2014)

Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers – a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale
por: Kostapanos, Michael S., et al.
Publicado: (2019)

Biological Therapies for Rheumatoid Arthritis: An Overview for the Clinician
por: Findeisen, Kate E, et al.
Publicado: (2021)

Tetrahydrobiopterin Improves Endothelial Function in Cardiovascular Disease: A Systematic Review
por: Wang, Qiongying, et al.
Publicado: (2014)

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
por: Douglas, Gillian, et al.
Publicado: (2018)

The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis
por: Triantafyllias, Konstantinos, et al.
Publicado: (2016)

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm
por: Chuaiphichai, Surawee, et al.
Publicado: (2018)

The role of epoxyeicosatrienoic acids in the cardiovascular system
por: Yang, L, et al.
Publicado: (2015)

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension()
por: Chuaiphichai, Surawee, et al.
Publicado: (2016)

Tumour necrosis factor inhibitors reduce aortic stiffness progression in patients with long-standing rheumatoid arthritis
por: Giollo, Alessandro, et al.
Publicado: (2021)

Biologic agents for rheumatoid arthritis—negotiating the NICE technology appraisals
por: Kiely, Patrick D. W., et al.
Publicado: (2012)

Reduced reward responsiveness in treatment resistant depression of middle-aged adults: Association with carotid artery stiffness and tetrahydrobiopterin
por: Barhwal, Kalpana K., et al.
Publicado: (2023)

The beneficial effects of Tai Chi exercise on endothelial function and arterial stiffness in elderly women with rheumatoid arthritis
por: Shin, Jeong-Hun, et al.
Publicado: (2015)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
por: Crabtree, Mark J., et al.
Publicado: (2011)

Tetrahydrobiopterin Administration Augments Exercise-Induced Hyperemia and Endothelial Function in Patients With Systemic Sclerosis
por: Machin, Daniel R., et al.
Publicado: (2022)

Infliximab improves vascular stiffness in patients with rheumatoid arthritis
por: Wong, M, et al.
Publicado: (2008)

Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation
por: De Pascali, Francesco, et al.
Publicado: (2014)

Central Tetrahydrobiopterin Concentration in Neurodevelopmental Disorders
por: Frye, Richard E.
Publicado: (2010)

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway
por: Pathak, Rupak, et al.
Publicado: (2015)

Value of Remission in Patients with Rheumatoid Arthritis: A Targeted Review
por: Ostor, Andrew J., et al.
Publicado: (2021)

Dietary Liberalization in Tetrahydrobiopterin-Treated PKU Patients: Does It Improve Outcomes?
por: Evers, Roeland A. F., et al.
Publicado: (2022)

Mast cell tetrahydrobiopterin contributes to itch in mice
por: Zschiebsch, Katja, et al.
Publicado: (2018)

Molecular genetics of phenylketonuria and tetrahydrobiopterin deficiency in Jordan
por: Carducci, Carla, et al.
Publicado: (2020)

Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity
por: Staats Pires, Ananda, et al.
Publicado: (2020)

Tetrahydrobiopterin deficiencies: Lesson from clinical experience
por: Bozaci, Ayse Ergul, et al.
Publicado: (2021)

Influencing Factors on the Use of Tetrahydrobiopterin in Patients with Phenylketonuria
por: Gao, Hui
Publicado: (2022)

Acute tetrahydrobiopterin supplementation attenuates sympathetic vasoconstrictor responsiveness in resting and contracting skeletal muscle of healthy rats
por: Jendzjowsky, Nicholas G., et al.
Publicado: (2014)

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling
por: Crabtree, Mark J., et al.
Publicado: (2013)

Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease
por: Fisk, Marie, et al.
Publicado: (2018)

Impact of morning stiffness on working behaviour and performance in people with rheumatoid arthritis
por: Mattila, Kalle, et al.
Publicado: (2014)

Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms
por: Zhang, Yixuan, et al.
Publicado: (2022)

Far-Infrared-Emitting Sericite Board Upregulates Endothelial Nitric Oxide Synthase Activity through Increasing Biosynthesis of Tetrahydrobiopterin in Endothelial Cells
por: Kim, Seonhee, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5suuc06n7kmflf7jbftqgoetuo