Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

BACKGROUND: Existing rodent models of vascular cognitive impairment (VCI) show abrupt changes in cerebral blood flow (CBF) and do not reliably replicate the clinical pathogenesis of VCI. We therefore aimed to develop a mouse model of VCI where CBF is gradually reduced, followed by subsequent progres...

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Detalles Bibliográficos
Autores principales: Hattori, Yorito, Enmi, Jun‐ichiro, Iguchi, Satoshi, Saito, Satoshi, Yamamoto, Yumi, Tsuji, Masahiro, Nagatsuka, Kazuyuki, Kalaria, Rajesh N., Iida, Hidehiro, Ihara, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802480/
https://www.ncbi.nlm.nih.gov/pubmed/26903005
http://dx.doi.org/10.1161/JAHA.115.002757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802480/
https://www.ncbi.nlm.nih.gov/pubmed/26903005
http://dx.doi.org/10.1161/JAHA.115.002757

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