Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease

BACKGROUND: The genetic basis of stroke susceptibility remains to be elucidated. STR1 quantitative trait locus (STR1/QTL) was identified on rat chromosome 1 of stroke‐prone spontaneously hypertensive rat (SHRSP) upon Japanese‐style stroke‐permissive diet (JD), and it contributes to 20% of the stroke...

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Detalles Bibliográficos
Autores principales: Rubattu, Speranza, Di Castro, Sara, Schulz, Herbert, Geurts, Aron M., Cotugno, Maria, Bianchi, Franca, Maatz, Henrike, Hummel, Oliver, Falak, Samreen, Stanzione, Rosita, Marchitti, Simona, Scarpino, Stefania, Giusti, Betti, Kura, Ada, Gensini, Gian Franco, Peyvandi, Flora, Mannucci, Pier Mannuccio, Rasura, Maurizia, Sciarretta, Sebastiano, Dwinell, Melinda R., Hubner, Norbert, Volpe, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802485/
https://www.ncbi.nlm.nih.gov/pubmed/26888427
http://dx.doi.org/10.1161/JAHA.115.002701