Cargando…

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease

BACKGROUND: The genetic basis of stroke susceptibility remains to be elucidated. STR1 quantitative trait locus (STR1/QTL) was identified on rat chromosome 1 of stroke‐prone spontaneously hypertensive rat (SHRSP) upon Japanese‐style stroke‐permissive diet (JD), and it contributes to 20% of the stroke...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rubattu, Speranza, Di Castro, Sara, Schulz, Herbert, Geurts, Aron M., Cotugno, Maria, Bianchi, Franca, Maatz, Henrike, Hummel, Oliver, Falak, Samreen, Stanzione, Rosita, Marchitti, Simona, Scarpino, Stefania, Giusti, Betti, Kura, Ada, Gensini, Gian Franco, Peyvandi, Flora, Mannucci, Pier Mannuccio, Rasura, Maurizia, Sciarretta, Sebastiano, Dwinell, Melinda R., Hubner, Norbert, Volpe, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802485/ https://www.ncbi.nlm.nih.gov/pubmed/26888427 http://dx.doi.org/10.1161/JAHA.115.002701

Ejemplares similares

Impact of a NDUFC2 Variant on the Occurrence of Acute Coronary Syndromes
por: Gallo, Giovanna, et al.
Publicado: (2022)

Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension
por: Gallo, Giovanna, et al.
Publicado: (2023)

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro
por: Stanzione, R, et al.
Publicado: (2015)

The C2238/αANP Variant Is a Negative Modulator of Both Viability and Function of Coronary Artery Smooth Muscle Cells
por: Rubattu, Speranza, et al.
Publicado: (2014)

Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms
por: Stanzione, Rosita, et al.
Publicado: (2020)

Uncoupling Protein 2 as a Pathogenic Determinant and Therapeutic Target in Cardiovascular and Metabolic Diseases
por: Stanzione, Rosita, et al.
Publicado: (2022)

Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation
por: Gallo, Giovanna, et al.
Publicado: (2020)

Beneficial Effects of Citrus Bergamia Polyphenolic Fraction on Saline Load-Induced Injury in Primary Cerebral Endothelial Cells from the Stroke-Prone Spontaneously Hypertensive Rat Model
por: Stanzione, Rosita, et al.
Publicado: (2023)

An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation
por: Forte, Maurizio, et al.
Publicado: (2021)

Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage
por: Pepe, Giuseppe, et al.
Publicado: (2021)

A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat
por: Stanzione, Rosita, et al.
Publicado: (2017)

In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit
por: Raffa, Salvatore, et al.
Publicado: (2017)

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats
por: Busceti, Carla L., et al.
Publicado: (2020)

Role of Uncoupling Protein 2 Gene Polymorphisms on the Risk of Ischemic Stroke in a Sardinian Population
por: Stanzione, Rosita, et al.
Publicado: (2022)

Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure
por: Raffa, Salvatore, et al.
Publicado: (2023)

Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains
por: Rubattu, Speranza, et al.
Publicado: (2015)

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat
por: Rubattu, Speranza, et al.
Publicado: (2017)

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease
por: Rubattu, Speranza, et al.
Publicado: (2016)

The T2238C Human Atrial Natriuretic Peptide Molecular Variant and the Risk of Cardiovascular Diseases
por: Rubattu, Speranza, et al.
Publicado: (2018)

C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP
por: Carnevale, Roberto, et al.
Publicado: (2017)

Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage Development
por: Rubattu, Speranza, et al.
Publicado: (2019)

Genome-Wide Association Studies in Myocardial Infarction and Coronary Artery Disease
por: Mannucci, Pier Mannuccio, et al.
Publicado: (2010)

Atrial Natriuretic Peptide Single Nucleotide Polymorphisms in Patients with Nonfamilial Structural Atrial Fibrillation
por: Francia, Pietro, et al.
Publicado: (2013)

Knockdown of NDUFC1 inhibits cell proliferation, migration, and invasion of hepatocellular carcinoma
por: Han, Fang, et al.
Publicado: (2022)

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway
por: Busceti, Carla L., et al.
Publicado: (2017)

Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
por: Pierelli, Giorgia, et al.
Publicado: (2017)

NDUFC1 Is Upregulated in Gastric Cancer and Regulates Cell Proliferation, Apoptosis, Cycle and Migration
por: Xu, Liang, et al.
Publicado: (2021)

Inhibition of miR‐155 Attenuates Detrimental Vascular Effects of Tobacco Cigarette Smoking
por: Frati, Giacomo, et al.
Publicado: (2020)

Natriuretic Peptides, Cognitive Impairment and Dementia: An Intriguing Pathogenic Link with Implications in Hypertension
por: Gallo, Giovanna, et al.
Publicado: (2020)

Bi‐allelic pathogenic variants in NDUFC2 cause early‐onset Leigh syndrome and stalled biogenesis of complex I
por: Alahmad, Ahmad, et al.
Publicado: (2020)

Clinical risk scores for the early prediction of severe outocomes in patients hospitalized for COVID-19: comment
por: Rossio, Raffaella, et al.
Publicado: (2021)

MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation
por: Schirone, Leonardo, et al.
Publicado: (2023)

Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism
por: Sticchi, Elena, et al.
Publicado: (2016)

Aging with Hemophilia: The Challenge of Appropriate Drug Prescription
por: Mannucci, Pier Mannuccio
Publicado: (2019)

Hemophilia therapy: the future has begun
por: Mannucci, Pier Mannuccio
Publicado: (2020)

Thrombotic thrombocytopenic purpura and other immune-mediated blood disorders following vaccination against SARS-CoV-2
por: Mannucci, Pier Mannuccio
Publicado: (2021)

Recombinant FVIII: the milestone of modern hemophilia treatment
por: Mannucci, Pier Mannuccio
Publicado: (2023)

CADASIL presenting as status migrainosus and persisting aura without infarction
por: Sacco, Simona, et al.
Publicado: (2008)

High-Throughput RNA Sequencing Reveals NDUFC2-AS lncRNA Promotes Adipogenic Differentiation in Chinese Buffalo (Bubalus bubalis L.)
por: Huang, Jieping, et al.
Publicado: (2019)

New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart
por: Ikeda, Yoshiyuki, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fm9u06nsev03sancs9qnneet9h