Zika virus and neurologic autoimmunity: the putative role of gangliosides

An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of inf...

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Autores principales: Anaya, Juan-Manuel, Ramirez-Santana, Carolina, Salgado-Castaneda, Ignacio, Chang, Christopher, Ansari, Aftab, Gershwin, M. Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802632/
https://www.ncbi.nlm.nih.gov/pubmed/27001187
http://dx.doi.org/10.1186/s12916-016-0601-y
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author Anaya, Juan-Manuel
Ramirez-Santana, Carolina
Salgado-Castaneda, Ignacio
Chang, Christopher
Ansari, Aftab
Gershwin, M. Eric
author_facet Anaya, Juan-Manuel
Ramirez-Santana, Carolina
Salgado-Castaneda, Ignacio
Chang, Christopher
Ansari, Aftab
Gershwin, M. Eric
author_sort Anaya, Juan-Manuel
collection PubMed
description An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.
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spelling pubmed-48026322016-03-22 Zika virus and neurologic autoimmunity: the putative role of gangliosides Anaya, Juan-Manuel Ramirez-Santana, Carolina Salgado-Castaneda, Ignacio Chang, Christopher Ansari, Aftab Gershwin, M. Eric BMC Med Commentary An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection. BioMed Central 2016-03-21 /pmc/articles/PMC4802632/ /pubmed/27001187 http://dx.doi.org/10.1186/s12916-016-0601-y Text en © Anaya et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Anaya, Juan-Manuel
Ramirez-Santana, Carolina
Salgado-Castaneda, Ignacio
Chang, Christopher
Ansari, Aftab
Gershwin, M. Eric
Zika virus and neurologic autoimmunity: the putative role of gangliosides
title Zika virus and neurologic autoimmunity: the putative role of gangliosides
title_full Zika virus and neurologic autoimmunity: the putative role of gangliosides
title_fullStr Zika virus and neurologic autoimmunity: the putative role of gangliosides
title_full_unstemmed Zika virus and neurologic autoimmunity: the putative role of gangliosides
title_short Zika virus and neurologic autoimmunity: the putative role of gangliosides
title_sort zika virus and neurologic autoimmunity: the putative role of gangliosides
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802632/
https://www.ncbi.nlm.nih.gov/pubmed/27001187
http://dx.doi.org/10.1186/s12916-016-0601-y
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