Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice

The Fan1 endonuclease is required for repair of DNA interstrand cross-links (ICLs). Mutations in human Fan1 cause karyomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsible or whether Fan1 nuclease activity is relevant. We show that Fan1 nuclease-defecti...

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Detalles Bibliográficos
Autores principales: Lachaud, Christophe, Slean, Meghan, Marchesi, Francesco, Lock, Claire, Odell, Edward, Castor, Dennis, Toth, Rachel, Rouse, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803050/
https://www.ncbi.nlm.nih.gov/pubmed/26980188
http://dx.doi.org/10.1101/gad.276287.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803050/
https://www.ncbi.nlm.nih.gov/pubmed/26980188
http://dx.doi.org/10.1101/gad.276287.115

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