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Application of Rigidity Theory to the Thermostabilization of Lipase A from Bacillus subtilis
Protein thermostability is a crucial factor for biotechnological enzyme applications. Protein engineering studies aimed at improving thermostability have successfully applied both directed evolution and rational design. However, for rational approaches, the major challenge remains the prediction of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803202/ https://www.ncbi.nlm.nih.gov/pubmed/27003415 http://dx.doi.org/10.1371/journal.pcbi.1004754 |