Functional Diversification after Gene Duplication: Paralog Specific Regions of Structural Disorder and Phosphorylation in p53, p63, and p73

Conformational and functional flexibility promote protein evolvability. High evolvability allows related proteins to functionally diverge and perhaps to neostructuralize. p53 is a multifunctional protein frequently referred to as the Guardian of the Genome–a hub for e.g. incoming and outgoing signal...

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Detalles Bibliográficos
Autores principales: dos Santos, Helena G., Nunez-Castilla, Janelle, Siltberg-Liberles, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803236/
https://www.ncbi.nlm.nih.gov/pubmed/27003913
http://dx.doi.org/10.1371/journal.pone.0151961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803236/
https://www.ncbi.nlm.nih.gov/pubmed/27003913
http://dx.doi.org/10.1371/journal.pone.0151961

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