Myonuclear transcription is responsive to mechanical load and DNA content but uncoupled from cell size during hypertrophy

Myofibers increase size and DNA content in response to a hypertrophic stimulus, thus providing a physiological model with which to study how these factors affect global transcription. Using 5-ethynyl uridine (EU) to metabolically label nascent RNA, we measured a sevenfold increase in myofiber transc...

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Detalles Bibliográficos
Autores principales: Kirby, Tyler J., Patel, Rooshil M., McClintock, Timothy S., Dupont-Versteegden, Esther E., Peterson, Charlotte A., McCarthy, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803305/
https://www.ncbi.nlm.nih.gov/pubmed/26764089
http://dx.doi.org/10.1091/mbc.E15-08-0585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803305/
https://www.ncbi.nlm.nih.gov/pubmed/26764089
http://dx.doi.org/10.1091/mbc.E15-08-0585

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