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Myonuclear transcription is responsive to mechanical load and DNA content but uncoupled from cell size during hypertrophy
Myofibers increase size and DNA content in response to a hypertrophic stimulus, thus providing a physiological model with which to study how these factors affect global transcription. Using 5-ethynyl uridine (EU) to metabolically label nascent RNA, we measured a sevenfold increase in myofiber transc...
Autores principales: | Kirby, Tyler J., Patel, Rooshil M., McClintock, Timothy S., Dupont-Versteegden, Esther E., Peterson, Charlotte A., McCarthy, John J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803305/ https://www.ncbi.nlm.nih.gov/pubmed/26764089 http://dx.doi.org/10.1091/mbc.E15-08-0585 |
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