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Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylation

Although proteins mediate highly ordered DNA organization in vivo, theoretical studies suggest that homologous DNA duplexes can preferentially associate with one another even in the absence of proteins. Here we combine molecular dynamics simulations with single-molecule fluorescence resonance energy...

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Detalles Bibliográficos
Autores principales: Yoo, Jejoong, Kim, Hajin, Aksimentiev, Aleksei, Ha, Taekjip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804163/
https://www.ncbi.nlm.nih.gov/pubmed/27001929
http://dx.doi.org/10.1038/ncomms11045