Different states of synaptotagmin regulate evoked versus spontaneous release

The tandem C2-domains of synaptotagmin 1 (syt) function as Ca(2+)-binding modules that trigger exocytosis; in the absence of Ca(2+), syt inhibits spontaneous release. Here, we used proline linkers to constrain and alter the relative orientation of these C2-domains. Short poly-proline helices have a...

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Detalles Bibliográficos
Autores principales: Bai, Hua, Xue, Renhao, Bao, Huan, Zhang, Leili, Yethiraj, Arun, Cui, Qiang, Chapman, Edwin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804166/
https://www.ncbi.nlm.nih.gov/pubmed/27001899
http://dx.doi.org/10.1038/ncomms10971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804166/
https://www.ncbi.nlm.nih.gov/pubmed/27001899
http://dx.doi.org/10.1038/ncomms10971

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