CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the centra...

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Detalles Bibliográficos
Autores principales: Gray, L R, Cowley, D, Welsh, C, Lu, H K, Brew, B J, Lewin, S R, Wesselingh, S L, Gorry, P R, Churchill, M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804184/
https://www.ncbi.nlm.nih.gov/pubmed/26303660
http://dx.doi.org/10.1038/mp.2015.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804184/
https://www.ncbi.nlm.nih.gov/pubmed/26303660
http://dx.doi.org/10.1038/mp.2015.111

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