ATX-LPA(1) axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation

The lipid mediator lysophosphatidic acid (LPA) signals via six distinct G protein-coupled receptors to mediate both unique and overlapping biological effects, including cell migration, proliferation and survival. LPA is produced extracellularly by autotaxin (ATX), a secreted lysophospholipase D, fro...

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Detalles Bibliográficos
Autores principales: Nishioka, Tatsuji, Arima, Naoaki, Kano, Kuniyuki, Hama, Kotaro, Itai, Eriko, Yukiura, Hiroshi, Kise, Ryoji, Inoue, Asuka, Kim, Seok-Hyung, Solnica-Krezel, Lilianna, Moolenaar, Wouter H., Chun, Jerold, Aoki, Junken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804234/
https://www.ncbi.nlm.nih.gov/pubmed/27005960
http://dx.doi.org/10.1038/srep23433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804234/
https://www.ncbi.nlm.nih.gov/pubmed/27005960
http://dx.doi.org/10.1038/srep23433

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