In vitro and in vivo drug disposition of cilengitide in animals and human

Cilengitide is very low permeable (1.0 nm/sec) stable cyclic pentapeptide containing an Arg‐Gly‐Asp motif responsible for selective binding to αvβ3 and αvβ5 integrins administered intravenously (i.v.). In vivo studies in the mouse and Cynomolgus monkeys showed the major component in plasma was uncha...

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Detalles Bibliográficos
Autores principales: Dolgos, Hugues, Freisleben, Achim, Wimmer, Elmar, Scheible, Holger, Krätzer, Friedrich, Yamagata, Tetsuo, Gallemann, Dieter, Fluck, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804314/
https://www.ncbi.nlm.nih.gov/pubmed/27069630
http://dx.doi.org/10.1002/prp2.217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804314/
https://www.ncbi.nlm.nih.gov/pubmed/27069630
http://dx.doi.org/10.1002/prp2.217

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