Amitriptyline protects against TNF‐α‐induced atrophy and reduction in synaptic markers via a Trk‐dependent mechanism

Neuritic degeneration and synaptic loss are features of both neuroinflammation and neurodegenerative disease. The tricyclic antidepressant amitriptyline has neurotrophic and anti‐inflammatory properties and acts as a novel agonist of the neurotrophin Trk receptors. Primary cortical neurons were trea...

Descripción completa

Detalles Bibliográficos
Autores principales: O'Neill, Eimear, Kwok, Billy, Day, Jennifer S., Connor, Thomas J., Harkin, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804321/
https://www.ncbi.nlm.nih.gov/pubmed/27069625
http://dx.doi.org/10.1002/prp2.195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804321/
https://www.ncbi.nlm.nih.gov/pubmed/27069625
http://dx.doi.org/10.1002/prp2.195

Ejemplares similares