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Active centromere and chromosome identification in fixed cell lines

BACKGROUND: The centromere plays a crucial role in ensuring the fidelity of chromosome segregation during cell divisions. However, in cancer and constitutional disorders, the presence of more than one active centromere on a chromosome may be a contributing factor to chromosome instability and could...

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Detalles Bibliográficos
Autores principales: Beh, Thian T., MacKinnon, Ruth N., Kalitsis, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804480/
https://www.ncbi.nlm.nih.gov/pubmed/27011768
http://dx.doi.org/10.1186/s13039-016-0236-x