Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo Model of Cancer

A small molecule inhibitor (QLT0267) targeting integrin-linked kinase is able to slow breast tumor growth in vivo; however, the mechanism of action remains unknown. Understanding how targeting molecules involved in intersecting signaling pathways impact disease is challenging. To facilitate this und...

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Detalles Bibliográficos
Autores principales: Kalra, Jessica, Dragowska, Weislawa H., Bally, Marcel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804727/
https://www.ncbi.nlm.nih.gov/pubmed/25940338
http://dx.doi.org/10.1369/0022155415587978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804727/
https://www.ncbi.nlm.nih.gov/pubmed/25940338
http://dx.doi.org/10.1369/0022155415587978

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