Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K(+) channels

Hypoxic pulmonary hypertension (PH) is a common disease characterized by a disturbance to the balance of apoptosis and cell proliferation in pulmonary artery smooth muscle cells (PASMCs). The anti-apoptotic protein, survivin, has been observed to be upregulated in pulmonary arteries (PAs) of chronic...

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Detalles Bibliográficos
Autores principales: ZHANG, SHUAI, LIU, BO, FAN, ZAIWEN, WANG, DONG, LIU, YING, LI, JIAN, WANG, NING, LIU, YI, ZHANG, BO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805101/
https://www.ncbi.nlm.nih.gov/pubmed/26957114
http://dx.doi.org/10.3892/mmr.2016.4977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805101/
https://www.ncbi.nlm.nih.gov/pubmed/26957114
http://dx.doi.org/10.3892/mmr.2016.4977

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