BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell

Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored. Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but...

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Detalles Bibliográficos
Autores principales: Deeney, Jude T., Belkina, Anna C., Shirihai, Orian S., Corkey, Barbara E., Denis, Gerald V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805167/
https://www.ncbi.nlm.nih.gov/pubmed/27008626
http://dx.doi.org/10.1371/journal.pone.0151329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805167/
https://www.ncbi.nlm.nih.gov/pubmed/27008626
http://dx.doi.org/10.1371/journal.pone.0151329

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