Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators

W1282X is a common nonsense mutation among cystic fibrosis patients that results in the production of a truncated Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Here we show that the channel activity of the W1282X-CFTR polypeptide is exceptionally low in excised membrane patches...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Hong, Jeong S., Rab, Andras, Sorscher, Eric J., Kirk, Kevin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805204/
https://www.ncbi.nlm.nih.gov/pubmed/27007499
http://dx.doi.org/10.1371/journal.pone.0152232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805204/
https://www.ncbi.nlm.nih.gov/pubmed/27007499
http://dx.doi.org/10.1371/journal.pone.0152232

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