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Evolutionary Conserved Positions Define Protein Conformational Diversity
Conformational diversity of the native state plays a central role in modulating protein function. The selection paradigm sustains that different ligands shift the conformational equilibrium through their binding to highest-affinity conformers. Intramolecular vibrational dynamics associated to each c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805271/ https://www.ncbi.nlm.nih.gov/pubmed/27008419 http://dx.doi.org/10.1371/journal.pcbi.1004775 |