The Hinge Region Strengthens the Nonspecific Interaction between Lac-Repressor and DNA: A Computer Simulation Study

LacI is commonly used as a model to study the protein-DNA interaction and gene regulation. The headpiece of the lac-repressor (LacI) protein is an ideal system for investigation of nonspecific binding of the whole LacI protein to DNA. The hinge region of the headpiece has been known to play a key ro...

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Detalles Bibliográficos
Autores principales: Sun, Lili, Tabaka, Marcin, Hou, Sen, Li, Lin, Burdzy, Krzysztof, Aksimentiev, Aleksei, Maffeo, Christopher, Zhang, Xuzhu, Holyst, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805274/
https://www.ncbi.nlm.nih.gov/pubmed/27008630
http://dx.doi.org/10.1371/journal.pone.0152002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805274/
https://www.ncbi.nlm.nih.gov/pubmed/27008630
http://dx.doi.org/10.1371/journal.pone.0152002

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