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Metabolism of hyperpolarized [1‐(13)C]pyruvate through alternate pathways in rat liver

The source of hyperpolarized (HP) [(13)C]bicarbonate in the liver during metabolism of HP [1‐(13)C]pyruvate is uncertain and likely changes with physiology. Multiple processes including decarboxylation through pyruvate dehydrogenase or pyruvate carboxylase followed by subsequent decarboxylation via...

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Detalles Bibliográficos
Autores principales: Jin, Eunsook S., Moreno, Karlos X., Wang, Jian‐Xiong, Fidelino, Leila, Merritt, Matthew E., Sherry, A. Dean, Malloy, Craig R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805436/
https://www.ncbi.nlm.nih.gov/pubmed/26836042
http://dx.doi.org/10.1002/nbm.3479